Abstract: The time course of changes in the levels of extracellular DA/DOPAC in rat striatum during brain ischemia and reperfusion was measured by the method of in vivo differential normal pulse voltammetry (DNPV). Acute cerebral ischemia of rats was produced by four-vessel occlusion. The effects of (+)-MK-801 and schizandrol A on the change of DA/DOPAC were investigated. The results showed that the DA/DOPAC peak in- creased markedly during 6 min of ischemia and, after reperfusion, the peak height decreased gradually. Both (+)-MK-801 and schizandrol A significantly inhibited the DA release after ischemia in the striatum.

Key words: Ischemia, Voltammetry, Dopamine, (+)MK-801, Schizandrol A