Investigation of the apoptotic mechanism in hippocampal and retinal neurons of db/db mice induced by Dihuangyinzi decoction

doi:10.5246/jcps.2024.10.066

Journal of Chinese Pharmaceutical Sciences ›› 2024, Vol. 33 ›› Issue (10): 918-931.DOI: 10.5246/jcps.2024.10.066

• Original articles • Previous Articles

Investigation of the apoptotic mechanism in hippocampal and retinal neurons of db/db mice induced by Dihuangyinzi decoction

Xiaodan Wang¹^,², Qinqing Li¹^,², Wanwei Gui¹^,², Dongyan Wu¹^,², Jinmiao Chai¹^,²^,^*(), Wenbin He¹^,², Junlong Zhang¹^,²^,^*()

¹ National International Joint Research Center of Molecular Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, Shanxi, China
² Shanxi Key Laboratory of Chinese Brain Diseases, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, Shanxi, China

Received:2024-03-12 Revised:2024-04-15 Accepted:2024-06-23 Online:2024-10-31 Published:2024-10-31
Contact: Jinmiao Chai, Junlong Zhang
Supported by:
National Natural Science Foundation (Grant No. 8227153727; 81874420).

Abstract

Supporting:

Xiaodan Wang, Qinqing Li, Wanwei Gui, Dongyan Wu, Jinmiao Chai, Wenbin He, Junlong Zhang. Investigation of the apoptotic mechanism in hippocampal and retinal neurons of db/db mice induced by Dihuangyinzi decoction[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(10): 918-931.

Figures/Tables 19

Table 1. Primer sequences for RT-qPCR.

Table 2. Results of S-PAL in db/db mice (x ± s, n = 5).

Table 3. Results of D-PAL in db/db mice (x ± s, n = 5).

Table 4. Response times and delay times between S-APL and D-APL in db/db mice (x ± s, n = 5).

Table 5. Changes in fasting blood glucose of the mice in each group (x ± s, n = 6).

Table 6. Positive expression levels of Bcl-2 and Bax in each group (x ± s, n = 6).

Table 7. Changes in fasting blood glucose of the mice in each group (x ± s, n = 6).

Table 8. Comparison of JNK/p38 MAPK pathway-related protein levels in the hippocampus and retinal tissues of mice (x ± s, n = 6).

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Investigation of the apoptotic mechanism in hippocampal and retinal neurons of db/db mice induced by Dihuangyinzi decoction

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