Effect of vitamin D supplementation on metabolic syndrome: a retrospective study

doi:10.5246/jcps.2023.03.017

Abstract

Abstract:

Vitamin D supplementation can improve metabolic syndrome (MetS)-related indicators. In the present study, we aimed to explore whether this improvement was dose-dependent in patients with low 25(OH)D levels. A retrospective study that recruited MetS patients from January 2017 to June 2019 was undertaken. They were divided into three groups according to the basic level of 25(OH)D. Chi-square test, one-way ANOVA, and T-test were used to examine the differences. A total of 111 patients were included in this study. The average age of them was 62.21 ± 13.35 years (21–89 years), and the mean serum 25(OH)D was 14.67 ± 5.75 nmol/L (4.6–27.5 nmol/L). After 29.92 ± 2.72 d, the serum 25(OH)D of each group was significantly increased (P < 0.05). The SBP, TG, and LDL-C were significantly decreased (P < 0.05), while TC and FBG were unaffected. There was no difference between the three groups (P > 0.05). Increasing the level of 25(OH)D could alleviate the pain caused by statins, even though the results of the statin gene suggested that the risk of myalgia was high. Taken together, vitamin D supplementation was beneficial for patients with MetS, and the benefit was not dose-related.

Key words: Metabolic syndrome, Vitamin D, 25(OH)D

Supporting:

Jing Yang, Xin Wang, Zihui Wang, Xiaojia Yu, Huaguang Wang, Ying Zhu, Boyu Li, Shuang Qiu, Zhuoling An. Effect of vitamin D supplementation on metabolic syndrome: a retrospective study[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(3): 200-206.

Figures/Tables 3

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