Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

doi:10.5246/jcps.2017.10.079

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (10): 697-708.DOI: 10.5246/jcps.2017.10.079

• Review • Next Articles

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

Yupeng Wang, Yi Sun^*, Xiaoping Pu^*

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2017-08-26 Revised:2017-09-20 Online:2017-10-31 Published:2017-09-27
Contact: Tel.: +86-010-82802648; +86-010-82802431, E-mail: sunyi@bjmu.edu.cn; pxp123@bjmu.edu.cn
About author:During 1990–1995, Dr. Pu obtained her M.Sc. and Ph.D. degree in Faculty of Pharmaceutical Sciences, Hokkaido University. In the period of 1995–1997, she did postdoctoral research at Institute of Basic Medical Sciences, Academy of Military Medical Sciences, China. During 1997–2002, she joined the department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences at Peking University as an Associate Professor. In 2002, Dr. Pu joined as a professor at School of Pharmaceutical Sciences in Peking University. She has published more than 100 articles in domestic and international journals, including about 60 SCI articles. She has also obtained 6 patents in China. Dr. Pu was granted the First-Class Natural Science Award (ranked No. 2) of the State Science and Technology Award by Ministry of Education of the People’s Republic of China. She has also directed several pre-clinical pharmacological and toxicological studies of new drugs. Dr. Pu has also authored 8 original or translated books including Manual of Protein Techniques, Innovative Pharmaceutical Chemistry, and Laboratory Guide in Experimental Pharmacology. Her main research interest is including Drug regulation of Parkinson’s disease genes and proteins, protective and therapeutic effects of TCM on experimental hepatic fibrosis and proteomic study on blood serum in morphine or New-type Drugs dependent animals.
Supported by:
National Natural Science Foundation of China (Grant No. 81401259, U1603128).

Abstract

Abstract:

Asthenozoospermia is a common cause of male infertility and is characterized by reduced forward motility of spermatozoa. The pathogenesis of asthenozoospermia remains unclear. DJ-1 is a ubiquitous protein, widely expressed in the liver, skeletal muscle, kidney, brain and testis. It has been found correlated with many diseases including male infertility. This review presents the novel concept that the endogenous antioxidant properties of DJ-1 in sperm is associated with asthenozoospermia. Thus, DJ-1 is likely a new target for the treatment of asthenozoospermia.

Key words: Asthenozoospermia, DJ-1, Oxidative stress, Mitochondria

CLC Number:

R969

Supporting:

Yupeng Wang, Yi Sun, Xiaoping Pu. Endogenous antioxidant DJ-1: A potential target for asthenozoospermia[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(10): 697-708.

References

[1] Thanaboonyawat, I.; Chantrapanichkul, P.; Petyim, S.; Kaewjunun, C.; Laokirkkiat, P.; Choavaratana, R. Arch. Gynecol. Obstet. 2017, 296, 589-596.

[2] Bonanno, O.; Romeo, G.; Asero, P.; Pezzino, F.M.; Castiglione, R.; Burrello, N.; Sidoti, G.; Frajese, G.V.; Vicari, E.; D’Agata, R. Reproduction. 2016, 152, 695-704.

[3] Singh, A.; Jahan, N.; Radhakrishnan, G.; Banerjee, B.D. J. Clin. Diagn. Res. 2016, 10, 14-17.

[4] Ahmadinejad, F.; Geir Moller, S.; Hashemzadeh-Chaleshtori, M.; Bidkhori, G.; Jami, M.S. Antioxidants. 2017, 6.

[5] Chan, J.Y.; Chan, S.H. Pharmacol. Ther. 2015, 156, 69-74.

[6] Eslamian, G.; Amirjannati, N.; Rashidkhani, B.; Sadeghi, M.R.; Hekmatdoost, A. Andrologia. 2017, 49.

[7] Ambulkar, P.S.; Chuadhari, A.R.; Pal, A.K. J. Hum. Reprod. Sci. 2016, 9, 35-40.

[8] Organisation, W.H. Cambridge,UK: Cambridge University Press. 2000.

[9] Pescatori, E.S. Diagnosis of Infertility. Springer International Publishing. 2015, 23-32.

[10] Agarwal, A.; Nallella, K.P.; Allamaneni, S.S.; Said, T.M. Reprod. Biomed. Online. 2004, 8, 616-627.

[11] Skakkebaek, N.E.; Rajpertde, M.E.; Buck Louis, G.M.; Toppari, J.; Andersson, A.M.; Eisenberg, M.L.; Jensen, T.K.; Jørgensen, N.; Swan, S.H.; Sapra, K.J. Physiol. Rev. 2016, 96, 55- 97.

[12] Curi, S.M.; Ariagno, J.I.; Chenlo, P.H.; Mendeluk, G.R.; Pugliese, M.N.; Sardi Segovia, L.M.; Repetto, H.E.; Blanco, A.M. Syst. Biol. Reprod. Med. 2003, 49, 343.

[13] Dada, R.; Mahfouz, R.Z.; Kumar, R.; Venkatesh, S.; Shamsi, M.B.; Agarwal, A.; Talwar, P.; Sharma, R.K. Andrologia. 2011, 43, 368-372.

[14] Boman, J.M.; Libman, J.; Zini, A. J. Urol. 2008, 180, 2129-2132.

[15] Halliwell, B.; Gutteridge, J.M. Arch. Biochem. Biophys. 1986, 246, 501-514.

[16] Finkel, T.; Holbrook, N.J. Nature. 2000, 408, 239-247.

[17] Burton, G.J.; Jauniaux, E. Best Pract. Res. Clin. Obstet. Gynaecol. 2011, 25, 287-299.

[18] Agarwal, A.; Durairajanayagam, D.; Halabi, J.; Peng, J.; Vazquez-Levin, M. Reprod. Biomed. Online. 2014, 29, 32-58.

[19] Cui, H.; Kong, Y.; Zhang, H. J. Signal Transduction. 2012, 2012, 13.

[20] Du Plessis, S.S.; Agarwal, A.; Halabi, J.; Tvrda, E. J. Assist. Reprod. Genet. 2015, 32, 509-520.

[21] Aitken, R.J.; Smith, T.B.; Jobling, M.S.; Baker, M.A.; De Iuliis, G.N. Asian. J. Androl. 2014, 16, 31-38.

[22] Fisher, H.M.; Aitken, R.J. J. Exp. Zool. 1997, 277, 390-400.

[23] Wolff, H.; Politch, J.A.; Martinez, A.; Haimovici, F.; Hill, J.A.; Anderson, D.J. Fertil. Steril. 1990, 53, 528-536.

[24] Sharma, R.K.; Pasqualotto, A.E.; Nelson, D.R.; Jr, T.A.; Agarwal, A. J. Androl. 2001, 22, 575-583.

[25] Saleh, R.A.; Agarwal, A.; Kandirali, E.; Sharma, R.K.; Jr, A.J.T.; Nada, E.A.; Evenson, D.P.; Alvarez, J.G. Fertil. Steril. 2002, 78, 1215-1224.

[26] Gilguzman, E. Hum. Reprod. 2001, 16, 1922.

[27] Agarwal, A.; Mulgund, A.; Sharma, R.; Sabanegh, E. Syst. Biol. Reprod. Med. 2014, 60, 206-216.

[28] Koppers, A.J.; De Iuliis, G.N.; Finnie, J.M.; Mclaughlin, E.A.; Aitken, R.J. J. Clin. Endocrinol. Metab. 2008, 93, 3199-3207.

[29] Macanovic, B.; Vucetic, M.; Jankovic, A.; Stancic, A.; Buzadzic, B.; Garalejic, E.; Korac, A.; Korac, B.; Otasevic, V. Dis. Mark. 2015, 2015, 436236.

[30] Chen, K.; Mai, Z.; Zhou, Y.; Gao, X.; Yu, B. Tohoku J. Exp. Med. 2012, 228, 259-266.

[31] Liu, J.; Peng, Z.; Wang, W.T.; Ning, L.; Xin, L.; Shen, X.F.; Wang, Y.W.; Yan, L. J. Urol. 2015, 195, 706-712.

[32] Yu, B.; Ding, Q.; Zheng, T.; Jiang, L.; Li, Q.; Sun, X.; Bai, C.; Huang, Z. Andrologia. 2015, 47, 987-994.

[33] Aitken, R.J.; Jones, K.T.; Robertson, S.A. J. Androl. 2012, 33, 1096-1106.

[34] Rajender, S.; Rahul, P.; Mahdi, A.A. Mitochondrion. 2010, 10, 419-428.

[35] Ruiz-Pesini, E.; Díez-Sánchez, C.; López-Pérez, M.J.; Enríquez, J.A. Curr. Top. Dev. Biol. 2007, 77, 3-19.

[36] Piomboni, P.; Focarelli, R.; Stendardi, A.; Ferramosca, A.; Zara, V. Int. J. Androl. 2012, 35, 109-124.

[37] Baccetti, B.; Bruni, E.; Gambera, L.; Moretti, E.; Piomboni, P. Fertil. Steril. 2004, 82, 463-468.

[38] Gopalkrishnan, K.; Padwal, V.; D’Souza, S.; Shah, R. Int. J. Androl. 1995, 18, 67-74.

[39] Piasecka, M.; Kawiak, J. Folia Histochem. Cytobiol. 2003, 41, 125-139.

[40] Rawe, V.Y.; Galaverna, G.D.; Acosta, A.A.; Olmedo, S.B.; Chemes, H.E. Hum. Reprod. 2001, 16, 879-886.

[41] Yang, S.M.; Li, H.B.; Wang, J.X.; Shi, Y.C.; Cheng, H.B.; Wang, W.; Li, H.; Hou, J.Q.; Wen, D.G. Asian. J. Androl. 2015, 17, 513-515.

[42] Pelliccione, F.; Micillo, A.; Cordeschi, G.; D’Angeli, A.; Necozione, S.; Gandini, L.; Lenzi, A.; Francavilla, F.; Francavilla, S. Fertil. Steril. 2011, 95, 641-646.

[43] Li, X.; Tian, M.; Zhang, G.; Zhang, R.; Feng, R.; Guo, L.; Yu, X.; Zhao, N.; He, X. Anal. Chem. 2017, 89, 3335-3344.

[44] Evenson, D.P.; Darzynkiewicz, Z.; Melamed, M.R. J. Histochem. Cytochem. 1982, 30, 279-280.

[45] Li, Z.; Zhou, Y.; Liu, R.; Lin, H.; Liu, W.; Xiao, W.; Lin, Q. Andrologia. 2012, 44, 157-163.

[46] Lucio, C.F.; Brito, M.M.; Angrimani, D.; Belaz, K.; Morais, D.; Zampieri, D.; Losano, J.; Assumpcao, M.; Nichi, M.; Eberlin, M.N.; Vannucchi, C.I. Reprod. Domest. Anim. 2017, 52, 208-213.

[47] Ruizpesini, E.; Lapeña, A.C.; Díez, C.; Alvarez, E.; Enríquez, J.A.; Lópezpérez, M.J. Clin. Chim. Acta. 2000, 300, 97-105.

[48] Ferramosca, A.; Focarelli, R.; Piomboni, P.; Coppola, L.; Zara, V. Int. J. Androl. 2008, 31, 337-345.

[49] Kao, S.H.; Chao, H.T.; Liu, H.W.; Liao, T.L.; Wei, Y.H. Fertil. Steril. 2004, 82, 66-73.

[50] Montiel-Sosa, F.; Ruiz-Pesini, E.; Enriquez, J.A.; Marcuello, A.; Diez-Sanchez, C.; Montoya, J.; Wallace, D.C.; Lopez-Perez, M.J. Gene. 2006, 368, 21-27.

[51] Nakada, K.; Sato, A.; Yoshida, K.; Morita, T.; Tanaka, H.; Inoue, S.; Yonekawa, H.; Hayashi, J. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 15148-15153.

[52] Kao, S.; Chao, H.T.; Wei, Y.H. Biol. Reprod. 1995, 52, 729-736.

[53] Ambulkar, P.S.; Waghmare, J.E.; Chaudhari, A.R.; Wankhede, V.R.; Tarnekar, A.M.; Shende, M.R.; Pal, A.K. J. Clin. Diagn. Res. 2016, 10, GC09-GC12.

[54] Nagakubo, D.; Taira, T.; Kitaura, H.; Ikeda, M.; Tamai, K.; Iguchi-Ariga, S.M.; Ariga, H. Biochem. Biophys. Res. Commun. 1997, 231, 509-513.

[55] Bonifati, V.; Rizzu, P.; van Baren, M.J.; Schaap, O.; Breedveld, G.J.; Krieger, E.; Dekker, M.C.; Squitieri, F.; Ibanez, P.; Joosse, M.; van Dongen, J.W.; Vanacore, N.; van Swieten, J.C.; Brice, A.; Meco, G.; van Duijn, C.M.; Oostra, B.A.; Heutink, P. Science. 2003, 299, 256-259.

[56] Giaime, E.; Sunyach, C.; Druon, C.; Scarzello, S.; Robert, G.; Grosso, S.; Auberger, P.; Goldberg, M.S.; Shen, J.; Heutink, P.; Pouyssegur, J.; Pages, G.; Checler, F.; Alves da Costa, C. Cell Death Differ. 2010, 17, 158-169.

[57] Wagenfeld, A.; Gromoll, J.; Cooper, T.G. Biochem. Biophys. Res. Commun. 1998, 251, 545-549.

[58] Wagenfeld, A.; Yeung, C.H.; Strupat, K.; Cooper, T.G. Biol. Reprod. 1998, 58, 1257-1265.

[59] Klinefelter, G.R.; Laskey, J.W.; Ferrell, J.; Suarez, J.D.; Roberts, N.L. J. Androl. 1997, 18, 139-150.

[60] Boe-Hansen, G.B.; Rego, J.P.; Crisp, J.M.; Moura, A.A.; Nouwens, A.S.; Li, Y.; Venus, B.; Burns, B.M.; McGowan, M.R. Anim. Reprod. Sci. 2015, 162, 20-30.

[61] Favareto, A.P.; Rodello, L.; Taconeli, C.A.; Bicudo, S.D.; Klinefelter, G.R.; Kempinas, W.G. Reprod. Domest. Anim. 2010, 45, 323-330.

[62] Wagenfeld, A.; Yeung, C.H.; Shivaji, S.; Sundareswaran, V.R.; Ariga, H.; Cooper, T.G. J. Androl. 2000, 21, 954-963.

[63] Klinefelter, G.R.; Welch, J.E.; Perreault, S.D.; Moore, H.D.; Zucker, R.M.; Suarez, J.D.; Roberts, N.L.; Bobseine, K.; Jeffay, S. J. Androl. 2002, 23, 48-63.

[64] Klinefelter, G.R. Anim. Reprod. Sci. 2008, 105, 90-103.

[65] An, C.N.; Jiang, H.; Wang, Q.; Yuan, R.P.; Liu, J.M.; Shi, W.L.; Zhang, Z.Y.; Pu, X.P. Fertil. Steril. 2011, 96, 19-23.

[66] Shen, S.; Wang, J.; Liang, J.; He, D. World J. Urol. 2013, 31, 1395-1401.

[67] Sun, Y.; Zhang, W.J.; Zhao, X.; Yuan, R.P.; Jiang, H.; Pu, X.P. Reproduction. 2014, 148, 249-257.

[68] Yokota, T.; Sugawara, K.; Ito, K.; Takahashi, R.; Ariga, H.; Mizusawa, H. Biochem. Biophys. Res. Commun. 2003, 312, 1342-1348.

[69] Taira, T.; Saito, Y.; Niki, T.; Iguchi-Ariga, S.M.; Takahashi, K.; Ariga, H. EMBO Rep. 2004, 5, 213-218.

[70] Im, J.Y.; Lee, K.W.; Woo, J.M.; Junn, E.; Mouradian, M.M. Hum. Mol. Genet. 2012, 21, 3013-3024.

[71] Jiang, T.; Sun, Q.; Chen, S. Prog. Neurobiol. 2016, 147, 1-19.

[72] Ottolini, D.; Cali, T.; Negro, A.; Brini, M. Hum. Mol. Genet. 2013, 22, 2152-2168.

[73] Joselin, A.P.; Hewitt, S.J.; Callaghan, S.M.; Kim, R.H.; Chung, Y.H.; Mak, T.W.; Shen, J.; Slack, R.S.; Park, D.S. Hum. Mol. Genet. 2012, 21, 4888-4903.

[74] Tai-Nagara, I.; Matsuoka, S.; Ariga, H.; Suda, T. Blood. 2014, 123, 41-50.

[75] Zhou, W.; Bercury, K.; Cummiskey, J.; Luong, N.; Lebin, J.; Freed, C.R. J. Biol. Chem. 2011, 286, 14941-14951.

[76] An, C.N.; Jiang, H.; Wang, Q.; Yuan, R.P.; Liu, J.M.; Shi, W.L.; Zhang, Z.Y.; Pu, X.P. Fertil. Steril. 2011, 96, 19-23.

[77] Van der Laan, M.; Hutu, D.P.; Rehling, P. Bba-Mol. Cell. Res. 2010, 1803, 732-739.

[78] Straub, S.P.; Stiller, S.B.; Wiedemann, N.; Pfanner, N. Biol. Chem. 2016, 397, 1097-1114.

[79] Hayashi, T.; Ishimori, C.; Takahashi-Niki, K.; Taira, T.; Kim, Y.C.; Maita, H.; Maita, C.; Ariga, H.; Iguchi-Ariga, S.M. Biochem. Biophys. Res. Commun. 2009, 390, 667-672.

[80] Canet-Aviles, R.M.; Wilson, M.A.; Miller, D.W.; Ahmad, R.; McLendon, C.; Bandyopadhyay, S.; Baptista, M.J.; Ringe, D.; Petsko, G.A.; Cookson, M.R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 9103-9108.

[81] Zhang, L.; Shimoji, M.; Thomas, B.; Moore, D.J.; Yu, S.W.; Marupudi, N.I.; Torp, R.; Torgner, I.A.; Ottersen, O.P.; Dawson, T.M.; Dawson, V.L. Hum. Mol. Genet. 2005, 14, 2063-2073.
[82] Wang, X.; Petrie, T.G.; Liu, Y.; Liu, J.; Fujioka, H.; Zhu, X. J. Neurochem. 2012, 121, 830-839.

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Shuang Li, Minggang Dong, Chunyan Guo, Shuangshuang Li, Sihan You, Ye Wan, Xinxing Liu. Taohong Siwu dispensing granules alleviate rotenone-induced SH-SY5Y cellular cytotoxicity by rescuing mitochondrial dysfunction and amino acid metabolism disarrangements [J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(5): 360-378.
[2]	Xiaoqing Chen, Bo Peng, Hongmei Jiang, Changxu Zhang, Haiyan Li, Ziyin Li. Salvianolic acid B alleviates oxidative stress in non-alcoholic fatty liver disease by mediating the SIRT3/FOXO1 signaling pathway [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(9): 698-710.
[3]	Ziyi Wang, Xiaoyan Liu, Yuanjun Zhu, Ye Liu, Pingping Zhang, Yinye Wang. The protective effect of W026B on global cerebral ischemia/reperfusion injury model in rats [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(2): 108-116.
[4]	Huijie Lv, Tuo Xv, Jun Peng, Gang Luo, Jianqin He, Sisi Yang, Tiancheng Zhang, Shuidong Feng, Hongyan Ling. Dihydromyricetin improves liver fat deposition in high-fat diet-induced obese mice [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(11): 824-839.
[5]	Mingkang Zhang, Yuyue Chen, Yan Zhou, Xin'an Wu. The alleviating effect of quercetin on carbon tetrachloride-induced liver fibrosis in rats and its underlying mechanism [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(11): 840-852.
[6]	Chunyang Han, Taotao Sun, Guangtai Fan, Yawei Liu, Cuiyan Liu. Protective effects of Polygonatum sibiricum against CCl4-induced acute liver injury in rats through oxidative stress and mitochondrial apoptotic pathways [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(4): 306-318.
[7]	Rong Li, Lihua Song, Jie Liu, Yang Bai, Yuming Du, Chunhua Lin, Xiuyuan Su, Zongxue Yu. Cardioprotective effect of Linagliptin on diabetic Wistar rats [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(4): 334-346.
[8]	Shihui Li, Kemeng Guo, Nining Yin, Mingzhu Shan, Yao Zhu, Ying Li. Teasaponin induces reactive oxygen species-mediated mitochondrial dysfunction in Candida albicans [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(11): 895-903.
[9]	Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang. The inhibitory activities of Urtica fissa to BPH [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 236-243.
[10]	Asia Abed Al-Mahmood, Limin Shu, Hyuck Kim, Christina Ramirez, Douglas Pung, Yue Guo, Wenji Li, Ah-Ng Tony Kong. Prostate cancer and chemoprevention by natural dietary phytochemicals [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(9): 633-650.
[11]	Shasha Ji, Yun Lei, Xiaotian Huang, Zhiqin Gao. Protective effects of β-dihydroagarofuran-type sesquiterpene against Aβ25-35-induced neuronal apoptosis and oxidative damage [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 582-589.
[12]	Lidan Bai, Xue Li, Qing Chang, Rui Wu, Jing Zhang, Xiaoda Yang. Cinnamaldehyde promotes mitochondrial function and reduces Aβ toxicity in neural cells [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 605-613.
[13]	Hongjun Xie, Lei Liu, Fan Zeng, Limin Mu, Yao Zhao, Yan Yan, Yingjie Hu, Jiashuan Wu, Yingzi Bu, Jingying Zhang, Wanliang Lu. Efficacy and mechanism of antiresistant vinorelbine liposomes in treating resistant breast cancer cells [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(7): 489-501.
[14]	Qian Yang, Gang Chen, Yang Yang, Xueting Cai, Zhonghua Pang, Chunping Hu, Shuangquan Zhang, Peng Cao. Formononetin ameliorates DSS-induced ulcerative colitis in mice through induction of Nrf2 in colons [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(3): 178-188.
[15]	Conghui Zhang, Xiuling Wang, Xiaolin Liang, Honglei Zhang, Qinghong Hao. Effects of (–)-5-hydroxy-equol on the lifespan and stress resistance of Caenorhabditis elegans [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(6): 378-384.