Rhein: a novel potential antitumor drug

doi:10.5246/jcps.2016.05.036

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (5): 321-328.DOI: 10.5246/jcps.2016.05.036

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Rhein: a novel potential antitumor drug

Lu Yu¹, Guodong Yao², Weicheng Ma^1*

1. Department of Clinical pharmacy, Ningbo Urology and Nephrology hospital, Ningbo 315400, China
2. China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2016-01-15 Revised:2016-02-22 Online:2016-05-30 Published:2016-02-26
Contact: Tel./Fax: +86-0574-55662548, E-mail: weichengma@126.com
About author:Professor Ma graduated from Department of Traditional Chinese Medicine College of Zhejiang Chinese Medical University in 1991. From 1991 to 2005, he served in pharmacy department of Ningbo Yinzhou People’s Hospital as a herbalist (1991), charge herbalist (1998), deputy director herbalist (2005). From 2006 to now, he served in pharmacy department of Ningbo Urology and Nephrology Hospital as deputy director herbalist (2006), director herbalist (2010). He was also lectured in the School of Ningbo University as a professor. During that period, he went to University of Illinois Chicago Branch as a visiting scholar in 2015. Over these years, he has specialized in hospital pharmacy and clinical pharmacy and serves as member of the editorial board for professional publications. Professor Ma has published more than 50 associated papers in domestic and international journals.

Abstract

Abstract:

Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is an anthraquinone compound enriched in the rhizome of rhubarb (Rheum palmatum or Rheum tanguticum Maxim), a traditional Chinese medicine herb. Natural product compounds are a source of novel therapeutic agents. Rhein has been initially identified as an anti-inflammatory and anti-oxidant agent. Recent studies indicate that rhein may also have an antitumor effect. However, the molecular mechanisms are still unclear. This review aims to summarize the research of rhein to better understand the anti-tumor activities by targeting cell cycle arrest, apoptosis, invasion, and metastasis of cancer cells. Meanwhile, we also intend to give an overview of the mechanisms identified so far. The breakthrough findings may shed light on using rhein as a targeted-cancer therapy.

Key words: Rhein, Cancer cells, Apoptosis, Cell cycle arrest

CLC Number:

R284

Supporting:

Lu Yu, Guodong Yao, Weicheng Ma. Rhein: a novel potential antitumor drug[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(5): 321-328.

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Rhein: a novel potential antitumor drug

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