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Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (3): 224-227.DOI: 10.5246/jcps.2016.03.027

• Short communication • Previous Articles     Next Articles

Inhibition of protein tyrosine phosphatase 1B by triterpenes isolated from Potentilla discolor Bge

Zhendong Tuo, Na Li, Jialin Li, Shizhou Qi, Banban Li, Le Zhang, Long Cui*   

  1. College of Pharmacy, Beihua University, Jilin 132013, China
  • Received:2015-10-25 Revised:2015-11-28 Online:2016-03-29 Published:2015-12-09
  • Contact: Tel.: +86-13604471092, +86-18604498621, E-mail: cuilong71@163.com
  • Supported by:
    Science and Technology Development Program of Jilin Province (Grant No. 20150101225JC).

Abstract:

Seven oleanene triterpenes were isolated from the roots of Potentilla discolor Bge and their structures were identified as3-oxoolean-12-en-27-oic acid (1), gypsogenic acid (2), 3α-hydroxyolean-12-en-27-oic acid (3), 3β-hydroxyolean-12-en-27-oic acid (4), aceriphyllic acid A (5), aceriphyllic acid A methyl ester (6), and oleanolic acid (7). Compounds 17 inhibited protein tyrosine phosphatase 1B (PTP1B) activity, with IC50 values ranging from (7.5±0.5) to (22.7±0.5) μmol/L. Among the isolates, compounds 1, 2, 3 and 7 from thePotentilla discolor Bge were found to exhibit selective PTP1B inhibitory activity.

Key words: Potentilla discolor Bge, Protein tyrosine phosphatase 1B, Triterpenes

CLC Number: 

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