Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial

doi:10.5246/jcps.2014.09.084

Journal of Chinese Pharmaceutical Sciences ›› 2014, Vol. 23 ›› Issue (9): 654-659.DOI: 10.5246/jcps.2014.09.084

• Original articles • Previous Articles Next Articles

Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial

Chunjing Li¹, Xiaolan Yu², Dongxin Wang^1*, Yuan Qu¹, Jia Liu³, Dongliang Mu¹

1. Departments of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China
2. Department of Gynecology planning care ward, Peking University First Hospital, Beijing 100034, China
3. Gynecological Operating Center, Peking University First Hospital, Beijing 100034, China

Received:2014-03-24 Revised:2014-05-12 Online:2014-09-23 Published:2014-05-15
Contact: Tel.: 86-10-13910731903

Abstract

Abstract:

Although parecoxib plays an important role in pain management after ambulatory gynecological surgery, its exact effect remains to be fully elucidated. In the present study, we aimed to investigate the effect of parecoxib pretreatment in reducing pain intensity after ambulatory gynecological surgery. A total of 200 female patients who were scheduled to selective ambulatory gynecological surgery were randomly divided into two groups. Patients in the control group received normal saline as placebo, whereas 40 mg parecoxib was given to the patients in the parecoxib group 30 min prior to anesthesia induction. Visual analoguescore (0 mm = no pain, and 100 mm = most severe pain) was used to evaluate postoperative pain severity. Pain scores were significantly lower in the parecoxib group than those in the control group after surgery. Compared with the control group, the incidence of intraoperative hypoxemia was significantly lower, and the recovery time from end of anesthesia to eye opening and birth date recollection were significantly shorter in the parecoxib group. Patients in the parecoxib group also had significantly improved overall satisfaction than those in the control group.

Key words: Parecoxib, Postoperative pain, Ambulatory surgery, Gynecology

CLC Number:

R711

Supporting:

Chunjing Li, Xiaolan Yu, Dongxin Wang, Yuan Qu, Jia Liu, Dongliang Mu. Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(9): 654-659.

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Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial

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