Anti-tumor activity of Hedyotis diffusa Willd. in mice

doi:10.5246/jcps.2013.03.039

Abstract

Abstract:

The whole plant with root of Hedyotis diffusa Willd. (AE) has been demonstrated to have anti-inflammatory, antioxidant, and anti-bacterial activities. In our study, we aim to examine the anti-tumor effect of alcoholic extract of AE in mice implanted with sarcoma S180 cells (SBT mice). We also compared the immune system function and the life span of SBT mice with that of control mice. We found that AE displayed a significant inhibitory effect on solid tumor growth, as well as increased the life span. At the dose of 10 mg/kg body weight, both tumor weight and volume were decreased significantly. We also measured several immune function markers, inlcuding spleen index (SI), thymus index (TI) and parameters of hematological. We observed no reduce in these markers, indicating that AE could inhibit tumor growth without affecting immune function in SBT mice.

Key words: Hedyotis diffusa Willd., Anti-tumor, Immunomodulatory, Iridoid, E-6-O-p-coumaroyl scandoside methyl ester

CLC Number:

R285.5

Supporting:

Yingfeng Wang^*, Yi Zheng, Baoshan Ku, Haiyan Yao, Guangyin Yao, Yangli Wan. Anti-tumor activity of Hedyotis diffusa Willd. in mice[J]. , DOI: 10.5246/jcps.2013.03.039.

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