Effects of 95% ethanol extract of Aquilaria sinensis leaves on hyperglycemia in diabetic db/db mice

doi:10.5246/jcps.2011.06.079

Abstract

Abstract:

The leaves of Aquilaria sinensis (Lour.) Gilg have been used in folk medicine for the treatment of diabetes in Guangdong Province, China. In this study, effects of ethanol extract of Aquilaria sinensis leaves on hyperglycemia were investigated in diabetic db/db mice. After 4 weeks of administration, the 95% ethanol (EtOH) extract of Aquilaria sinensis leaves (AE), especially at high dose level (600 mg/kg), activated AMP-activated protein kinase (AMPK), resulting in reduced fasting blood glucose and glycosylated hemoglobin levels in db/db mice. In addition, the oral glucose tolerance test (OGTT test) showed that AE could remarkably improve insulin resistance. Compared to Thiazolinediones (TZDs), no weight gain was observed after AE administration, which is a severe side effect of TZDs. The data suggested that AE could act as an activator of AMPK, and might be used as an alternative to TZDs in the management of obesity-related diabetes.

Key words: Aquilaria sinensis, Diabetes, db/db mice, Fasting glucose level, HbA1c, OGTT, AMPK

CLC Number:

Supporting:

Shan Jiang, Yong Jiang, You-Fei Guan, Peng-Fei Tu^*, Ke-Yuan Wang, Jin-Ming Chen . Effects of 95% ethanol extract of Aquilaria sinensis leaves on hyperglycemia in diabetic db/db mice[J]. , DOI: 10.5246/jcps.2011.06.079.

[1]	Ying Fu, Simo Liu, Yan Ma, Nannan Wu. Canagliflozin, an inhibitor of sodium-glucose co-transporter 2, advances in the treatment of type 2 diabetes [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(8): 569-588.
[2]	Weiping Zhao, Qi Ge, Zijun Ding, Leizhi Pan, Ziqing Gu, Yang Liu, Hua Cai. Network pharmacology and metabolomics-based detection of the potential pharmacological effects of the active components in Chrysanthemum morifolium 'Chuju' [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(6): 412-428.
[3]	Rui Li, Yanru Kong. Effects of linagliptin on inflammatory factors and arteriosclerosis in patients with newly diagnosed type 2 diabetes mellitus [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(8): 692-698.
[4]	Ye Yao, Xiangfei Jiu, Siyuan Wang, Wei Lu, Tianyan Zhou. Mechanism-based pharmacokinetic/pharmacodynamic modeling of the effects of sitagliptin on DPP-4 activity, insulin and glucose in diabetic rats [J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(6): 371-382.
[5]	Yihua Hong, Tongtong Liu, Yanjun Liu, Jingxuan Wu, Xiaogai Yang. Vanadium compounds induce stronger growth suppression in PTEN-deficient prostate cancer cells by ROS-mediated mechanism [J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(6): 432-439.
[6]	Qin Hu, Hulin Tang, Hong Shao. Incretin-based therapies for type 2 diabetes with nonalcoholic fatty liver disease: a systematic review and meta-analysis [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(3): 206-214.
[7]	Li Yao, Fangfang Fan, Lan Hu, Shengjun Zhao, Lili Zheng. Efficacy and safety of saxagliptin in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(2): 128-139.
[8]	Xiaohui Xie, Fei Wang, Jiayu Cui. The impact of obesity in managing diabetes [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(6): 412-418.
[9]	Mohd Fasih Ahmad, Raj K. Keservani, D J Mani Babu. Interaction study between Ocimum sanctum and Glimepiride (sulfonylurea derivative) in diabetic rats [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(3): 156-163.
[10]	Xiaohui Bai, Youhong Niu, Decai Xiong, Yanfen Wu, Yunsen Li. Advances of N-terminal modifications of GLP-1 and their applications for the treatment of type 2 diabetes [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(11): 701-711.
[11]	Ziwei Wang, Na Wang, Meiling Huang, Xiaoda Yang. The long-term toxicity and hypoglycemic effect of vanadyl complexes on non-diabetic and type II diabetic mice [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(11): 734-743.
[12]	Simin Yang, Liyan Ji, Linling Que, Kui Wang, Siwang Yu. Metformin activates Nrf2 signaling and induces the expression of antioxidant genes in skeletal muscle and C2C12 myoblasts [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(12): 837-843.
[13]	Fan Yi, Dong Li, Weizhi Ma, Quan Du^*. GLP-1 biology and GLP-1 based antidiabetic therapy [J]. , 2013, 22(1): 7-27.
[14]	Khuram Shehzad, Maria Rasool, Mahjabeen Saleem^*, Mamoona Naz . Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population [J]. , 2012, 21(3): 259-264.
[15]	Qing Shen, Shan-Shan Gao, Yi-Ni Xie, Li-Cheng Ling, Feng Gao^*. Curative effect of novel oral carbon microspheres on streptozotocin-induced diabetes mellitus in rats [J]. , 2012, 21(3): 234-241.

Effects of 95% ethanol extract of Aquilaria sinensis leaves on hyperglycemia in diabetic db/db mice

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments