Intestinal permeability of atractylenolides across the human Caco-2 cell monolayer model

doi:10.5246/jcps.2011.05.064

• Full Papers • Previous Articles Next Articles

Intestinal permeability of atractylenolides across the human Caco-2 cell monolayer model

Jie Guo, Wei Xu, Xiu-Wei Yang^*

State Key Laboratory of Natural and Biomimetic Drugs; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2011-05-30 Revised:2011-08-10 Online:2011-09-20 Published:2011-09-20
Contact: Xiu-Wei Yang*

Abstract

Abstract:

The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The Papp values of atractylenolide I, II, and III were all at the level of 10^-5 cm/s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported.

Key words: Atractylenolide I, Atractylenolide II, Atractylenolide III, Caco-2 cell monolayer model, Intestinal permeability

CLC Number:

Supporting:

Jie Guo, Wei Xu, Xiu-Wei Yang^* . Intestinal permeability of atractylenolides across the human Caco-2 cell monolayer model [J]. , DOI: 10.5246/jcps.2011.05.064.

[1]	Xulong Chen, Zhengge Liao, Cheng Li, Guoyong Huang, Yunyan Song, Wei Dong, Abid Naeem, Xinli Liang. In vitro metabolism and inhibitory effects of atractylenolide II on various hepatic CYPs in HLMs [J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(8): 645-656.
[2]	Li-Qin Zhang, Ying-Dong Huang, Xiu-Wei Yang^*. Intestinal permeability of liquiritin and isoliquiritin in the Caco-2 cell monolayer model [J]. , 2010, 19(6): 451-458.

Intestinal permeability of atractylenolides across the human Caco-2 cell monolayer model

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 2

Recommended Articles

Metrics

Comments