Secondary metabolites from marine derived fungus Penicillium terrestre

doi:10.5246/jcps.2010.06.065

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Secondary metabolites from marine derived fungus Penicillium terrestre

Hui Liu, Jian Chen, Zhi-Wei Deng, Hua-Rong Huang, Wen-Han Lin^*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
2. Key Laboratory of Pesticide & Chemical Biology, Central China Normal University, Wuhan 430079, China
3. Analytical and Testing Center, Beijing Normal University, Beijing 100072, China

Received:2010-04-12 Revised:2010-10-15 Online:2010-11-30 Published:2010-11-30
Contact: Wen-Han Lin*

Abstract

Abstract:

Chemical examination of an unidentified sponge associated marine fungus Penicillium terrestre resulted in the isolation of eight compounds. Their structures are identified as cyclo (glycyl-D-proline) (1), cyclo (L-prolyl-L-alanine) (2), cyclo (L-prolyl-D-alanine) (3), cyclo (L-leucyl-trans-4-hydroxy-L-proline) (4), cyclo (L-leucyl-cis-4-hydroxy-D-proline) (5), cyclo (L-trans-(4-hydroxyprolinyl)-L-phenylalanine) (6), hexylitaconic acid (7), and hexylitaconic methylate (8), based on spectroscopic analysis (1D, 2D NMR). Compounds 7, 8 were obtained from the genus Penicillium for the first time, while compounds 1-6 were isolated from the fungus Penicillium terrestre for the first time.

Key words: Penicillium terrestre, Chemical components, Fungus, Cyclodipeptide, Organic acid

CLC Number:

Supporting:

Hui Liu, Jian Chen, Zhi-Wei Deng, Hua-Rong Huang, Wen-Han Lin^* . Secondary metabolites from marine derived fungus Penicillium terrestre [J]. , DOI: 10.5246/jcps.2010.06.065.

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Secondary metabolites from marine derived fungus Penicillium terrestre

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