To systematically evaluate the establishment, operational framework, and preliminary outcomes of the Osteoporosis Medicine-Pharmacy Joint Clinic (OMPJC), this study aimed to develop an innovative and practice-oriented model to advance standardized prevention and management of osteoporosis. A total of 248 patients who attended the OMPJC at our hospital between April and September 2025 were initially enrolled. The joint clinic was structured around a multidisciplinary core team comprising senior orthopedic physicians and clinical pharmacists, delivering integrated, full-cycle care that spans diagnosis, pharmacotherapy optimization, and rehabilitation management. Key outcome measures included indices of medication standardization (rational drug use rate, incidence of adverse drug reactions, and patient adherence), biomarkers of bone metabolism (β-CTX, PINP, and 25(OH)D), and indicators of bone health improvement (fall incidence rate). Statistical analyses were conducted using SPSS version 22.0. Ultimately, 207 patients met the inclusion criteria and completed follow-up, with a mean age of (66.59 ± 10.41) years. Following implementation of the OMPJC intervention, the rational drug use rate increased to 91.78%, while the overall incidence of adverse drug reactions was 7.24%, with no serious adverse events reported. Medication adherence reached 86.96%, and exercise adherence was 76.81%. After 6 months of continuous management, serum levels of β-CTX and PINP were significantly reduced compared with baseline (P < 0.05), whereas 25(OH)D levels increased significantly (P < 0.05). Notably, the fall incidence rate declined from 5.3% prior to intervention to 1.4% after intervention. Through a structured multidisciplinary collaboration model, the OMPJC effectively addressed key limitations of conventional care, including non-standardized medication management, fragmented diagnostic and therapeutic processes, and insufficient patient engagement. The model substantially enhanced medication safety and therapeutic effectiveness, optimized bone metabolic parameters, and reduced fall risk. Collectively, these findings suggested that the OMPJC represented a scalable and reproducible clinical pathway for the standardized prevention and treatment of osteoporosis, with considerable potential for broader implementation.
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