This study investigates the lipid-lowering and hepatoprotective effects of Cyclocarya paliurus on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) mice. Cyclocarya paliurus extract (CCE) was found to be able to reduce cholesterol synthesis by promoting the binding of sterol regulatory element-binding protein (SREBP) to sterol regulatory elements, thereby inhibiting the expression of a gene encoding 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase). Due to the formation of ABCG5/8, heterodimers mediate the excretion of neutral sterols such as cholesterol. Hepatic ABCG5/8 excretes cholesterol directly into bile, and CCE lowers hepatic cholesterol by upregulating levels of cholesterol transport-related proteins ABCG5 and ABCG8, thereby lowering hepatic cholesterol and improving MASLD. CCE also increased the expression levels of inflammatory factors (such as TNF-α and IL-6) and oxidative stress-related genes (such as NRF2, KEAP1, and NQO1), decreased the levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in the liver, increased the amount of HDL-C in the liver, and alleviated liver damage from MASLD.
Bao, X.A. et al. / J. Chin. Pharm. Sci. 2025, 34 (4), 305–320.
本作品采用知识共享署名-非商业性使用 4.0 国际许可协议进行许可。
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