Two total synthetic routes for the preparation of myricetin were designed and explored. It was validated that the route presented an efficient approach to synthesizing myricetin, starting from commercially available and inexpensive phloroglucinol. Myricetin was synthesized with an overall yield of 60% across three steps without the need of column chromatography separation. The successful preparation of myricetin on a 25-g scale underscored the potential of this approach.
Gu, H.J. et al. / J. Chin. Pharm. Sci. 2024, 33 (12), 1101–1109.
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