Abstract: The effects of Lingzhi (Ganoderma lucidum) on hemorrheology parameters and symptoms of hypertensive patients with hyperlipidemia, sequelae of cerebral thrombosis and coronary heart disease are studied. The Lingzhi extract was given to 33 patients (15 male, 18 female, 65±8 years old) in dosage of 110 mg qid po for 2 weeks. The blood viscosity was improved after treatment. The results showed that whole blood viscosity (at high shear rate and low shear rate) and plasma viscosity were significantly decreased(P<0.01). Lingzhi showed the effect of reducing blood pressure simultaneously. Several symptoms were also improved. However, there were no significant changes in haematocrit and erythrocyte sedimentation rate (P>0.05).In a few cases there occurred adverse reactions of palpitation and restlessness.

Key words: Ganoderma lucidum, Hemorrheology, Thrombosis