Abstract: A rotundine-polyion complex (PIC) release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan (CMGM) solution on the granular surface. The granules have an average diameter of 1.38~1.53 mm and the drug content reaches 62.89%. The external release tests showed T50 to be 45 min and the total release time 4 h in an artificial gastric juice, while no more than 60% of the drug was released in the same period of time in an artificial intestinal fluid. The various factors affecting the external release were examined.

Key words: Rotundine, Polyion Complex, Chitosan, Konjac glucomannan, Drug release