Abstract: The experimental uveitis was induced by injecting lens protein into the antertor cham- ber of rabbit's eye. A special fluorophotometer was used for objectively measuring the flaoreseein level in the anterior chamber of the eve to rellect the degree of inflammation. When administered intravenously. The inhibitory effects of flufenamic acid and mefenamic acid on experimental uveius showed a dose-dependent relationship, The former at dosages 5.0.12.5 and 250 mg kg decreased the areas under the time-response curve to 22.3%.11.5% and 9.3% of the control, respectively: however the latter at dosages 6.2.12.5 and 25.0 mg/kg decreased the areas under the curve to 35.5%.21.0% and 8.6% of the control, respectively. When instilled by ocular route.50μl of 1% eye-drops of flufenmic acid or mefenamic acid lowered the fluoreseein levels of treated eyes as well as contra-lateral eyes. The areas under the time-response curve for treated eyes were decreased to 20.3% of the control and those of contra-lateral eyes to about 50% of the control. The results indicate that both flufenamic and mefenamic acids, applied intravenously or topically, can inhibit ocular inflammation.

Key words: Flufenamic acid, Mefenamic acid, Ocular inflammation