Abstract: In an attempt to demonstrate the biological activities of a short peptide. Arg-Gly-Asp-Ser (RGDS) was synthesized and used for bioassay, The data obtained here proved that RGDS obviously inhibited PAF- and/or ADP-induced platelet aggregation. The present paper revealed that RG-DS had vasodilative action and the cGMP accumulation may be one of the mechanisms of RGDS exerting bioactivities.

Key words: Arg-Gly-Asp-Ser(RGDS), Antiplatelet Aggregation, Vasodilation