Abstract: By using active principles of Chinese medicinal materials as lead compounds soquinoline derivatives have been designed and synthesized. Their chemical structures include bisbenzylisoquinoline, benzyl-isoquinoline and protoberberine. Their cardiovascular effects were studied involving α-adrenoceptor, adenosine A1, A2 and DPH-calcium channel radioreceptor assays.In addition, calmodulin inhibiting, calcium antagonistic potassium channel blocking and antiplatelet aggregation activities were also performed.It was found that compound VI19 was a new potassium channe blocker with α-adrenoceptor antagonism, compound V9, and V21 lowered blood pressure on various animal models with negative chronotropic action, compound VI13 possessed antiarrhythmic and antifi- brillation action, and it may be a candidate tot clinic evaluation.The structure-activity relationships deduced may provide a theoretical basis for further development of new agents.

Key words: Isoquinoline compounds, Cardiovascular drugs