Abstract: The results confirmed that diazepam inhibits the cholinesterase in rat serum, red cell, corpus striatum and diaphragm in vitro, that the higher the diazepam concentration, the stronger the cholinesterase inhibition, and that diazepam is a reversible inhibitor to acetylcholinesterase and diazepam has a stabilizing action on red cell membranes. The role of these effects of diazepam in the treatment of organic phosphate poisoning is discussed.

Key words: Diazepam, Cholinesterase, Organic phosphate, Membrane stabiliy