Abstract: The distribution of 3H-mitoxantrone polybutyl cyanoacrylate nanospheres 3H-DHAQ-PBCA-NS)in the viscera, muscle and tumors of human hepatocellular carcinoma (HCC)model in nude mice was studied with liquid scintillation counting techniique. The results showed that the 3H-DHAQ-PBCA-NS had remarkable liver targeting effect. The content of 3H-DHAQ-PBCA-NSin liver and heterotopic liver tumor was found to be 71.31±10.49% of total amount of drug in animal body. It was also found that the content of 3H-DHAQ-PBCA-NS in liver was higher than that in liver tissue, and the content of 3H-DHAQ-PBCA-NS in annpit tumor was higher than that in armpit muscle tissue, but had no significant difference; It provides an ideal preparation for the DHAQ admini-stration.

Key words: Mitoxantrone nanospheres, Liver cancer, Human hepatocellular carcinoma model in nude mice, Targeted drug delivery system