Abstract: Herein, the orthogonal test was used to optimize the preparation conditions and technique of mitoxantrone ethylcellulose microsphere (DHAQ-EC-MS)for liver arterial embolization.The dynamic dialysis method was used to study the drug release characteristics ofthe DRAQ-EC-MS.The suspension of DHAQ-EC-MS for clinical liver arterial embolization was prepared.The results show that the DHAQ-EC-MS is regular in morphology with a mean diameter of 110.24±38.19 μm and 86.5% of them within the range of 40-150μm, The drug loading is 12.5% and the embedding ratio is 55.6%. The release characteristics were in accordance with the single exponential model.The drug release equation is log(Y∞-Y) = -0.116t - 1.198 × 10^-3 (r = 0.9992, t50 = 2.6 h). The suspension is ofstable physical and chemical properties and is suitable for clinical use.

Key words: Mitoxantrone, Ethylcellulose microsphere, Liver arterial embolization