Abstract: P6A was able to increase coronary blood flow and improve hemodynamics in the coronary thrombosis model of dogs In the binding of fibrinogen to GP IIb/IIIa, RGD is the key sequence In the present paper the effects of the coupling compounds of P6A and its derivatives, QP6A with RGDS, RGDV and RGDF were tested The effects of the coupling compounds so obtained on carotid thrombosis in rats were investigated At the dose of 5 μmol/kg, RGDS and RGDV exhibited no antithrombotic effects, whereas at 2.5 μmol/kg RGDF decreased the dry-weight ofthrombus significantly On the other hand, P6A(5 μmol/kg)and QP6A(2.5 μmol/kg)showed significant antithrombosis activities.All of the coupling compounds, except P6A-RGDF and QP6A-RGDF, had potent antithrombosis effects.

Key words: P6A, RGD sequence, Anti-thrombosis