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Triptolide Induced Apoptosis of Eosinophils in Airway of Allergic Guinea Pigs

Wang Changzheng, Lai Kefang, Guo Xiaoming   

  1. Institute of Respiratory Medicine, Xinqiao, Hospital, Third Military Medical University Chongqing 400037
  • Received:1998-08-26 Revised:1999-01-19 Online:1999-09-15 Published:1999-09-15

Abstract: In this study, the effects of triptolide extract from a Chinese herb on eosinophilic apoptosis in allergic guinea pigs was explored. The .findings showed that triptolide could inhibit eosinophilic apoptosis and the expression of bc1-2 in eosinophils from allergic guinea pigs’ airway and would be of help in treatment of airway inflammation in allergic diseases such as asthma.

Key words: Allergy, Triptolide, Eosinophils, Apoptosis

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