Abstract: This report studied on pharmaceutical characteristics of the stealth liposome containing dau-norubicin (DNR). The shape, size, entrapment efficiency and stability of the daunorubicin stealth liposomes (DNRSL) were examined. Visible spectrophotometry and the HPLC method were established for determination of the DNR in the DNRSL. The release of DNR from DNRSL in HBS (pH 7.5) and rat serum at 37 °C were examined. The results showed that the DNRSL had high entrapment efficiency (>85%), small size and slow release.

Key words: Stealth liposomes, Stealth liposomes, Daunorubicin, Daunorubicin, Entrapment efficiency, Entrapment efficiency, Drug release in vitro, Drug release in vitro