Abstract: A simple, rapid and sensitive flow injection chemiluminescence (FI-CL) method has been developed for the determination of meloxicam. The method is based on the CL-emitting reaction between meloxicam and potassium permanganate in a hydrochloric acid medium, enhanced by formaldehyde (HCHO). Under optimum conditions, calibration curve over the range of 1.0–20.0 μg/mL was obtained. The proposed method was successfully applied to the determination of meloxicam in capsules with no evidence of interference from common excipients. The detection limit of this method was 25.6 ng/mL. The relative standard deviation was 2.1% for 10.0 μg/mL meloxicam. The sample throughput was found to be 120 samples/h.

Key words: Meloxicam, Meloxicam, Flow injection chemiluminescence, Flow injection chemiluminescence, Formaldehyde, Formaldehyde, Pharmaceutical analysis, Pharmaceutical analysis