Abstract: The properties of gelatin microspheres Zedoary turmeric oil (GMS-ZT) in vitro release were studied by the continuous flow system (CFS), which could simulate the actual state in vivo. The effects of sterilization, different flow rates, release medium, the amount of formaldehyde, the duration of cross-linking and the size of microspheres on the drug release were investigated. The results showed that these factors except the sterilization had influences on drug release and the drug release from the microspheres was slow. Eighty percent of the drug released after 12 h, and the release profiles in vitro could be described by the first-order dynamic model, and drug release was controlled by the matrix erosion and diffusion.

Key words: Zedoary turmeric oil, Zedoary turmeric oil, Curcumol, Curcumol, Gelatin microspheres, Gelatin microspheres, Drug release in vitro, Drug release in vitro