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The Alkaloids from Leaves of Croton hemiargyerius var. gymnodiscus

LIN Wen-han*, FU Hong-zheng, LI Jun, CHENG Gang, Roderick A.Barnes   

  1. 1.State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China;
    2.Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saude, Federal University of Rio de Janeiro, Rio de Janeiro 21941, Brasil
  • Received:2003-03-25 Revised:2003-08-10 Online:2003-09-15 Published:2003-09-15
  • Contact: LIN Wen-han*

Abstract: Aim Investigation of alkaloids from the leaves of Brazilian medicinal plant Croton hemiargyerius var. gymnodiscus. Methods Silica gel column chromatography was used repeatedly for the isolation and purification, and their structures were identified by extensive spectroscopy and comparison of the chemical and physical data with those of authentic samples reported in literature. Results Twelve alkaloids were isolated and their structures were identified. Conclusion Four new alkaloids named hemiargines A (1), B (5), C (6) and D (7), together with eight known alkaloids namely isocorydine (2), corydine (3), norcorydine (4), salutaridine (8), glaucine (9), tetrahydropalmatrubine (10), xylopinoine (11), and norlaudanosine (12) were isolated.

Key words: Csroton hemiargyerius, Csroton hemiargyerius, new alkaloids, new alkaloids, hemiargines A,B,C,D, hemiargines A,B,C,D

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