One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water

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One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water

Xu Yan, Ze-Mei Ge^*, Tie-Ming Cheng, Run-Tao Li^*

The State Key Laboratory of Natural and Biomimetic Drugs;
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Received:2008-09-15 Revised:2008-11-10 Online:2008-12-15 Published:2008-12-15
Contact: Run-Tao Li*

Abstract

Abstract: An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5-thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or α, β-unsaturated carbonyl compounds. The reactions were carried out in water in the presence of potassium phosphate within 2–4 h to afford the expected products in excellent yields.

Key words: 1,3,4-Oxadiazole-5-thioether, 1,3,4-Oxadiazole-5-thioether, One-pot synthesis, One-pot synthesis, Environmental-friendly, Environmental-friendly, Aqueous medium, Aqueous medium, Acylhydrazine, Acylhydrazine, Potassium phosphate, Potassium phosphate

Supporting:

Xu Yan, Ze-Mei Ge^*, Tie-Ming Cheng, Run-Tao Li^*
. One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water
[J]. .

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