Structure modifications based on KRN7000 and their SARs in activating NKT cells

Abstract

Abstract:

α-Galactosylceramides, which can be recognized by natural killer T (NKT) cells, are now attracting more and more attetion due to their therapeutic potential in cancer, infection and autoimmune diseases. Advances have been achieved in discovering compounds with better activities and efforts have been made to understand the structure-activity relationships (SARs) of these NKT cell ligands. In this review, we discuss the structure modifications based on KRN7000, the principal glycolipid used in the study of NKT cell stimulation, and the SARs based on these modified structures.

Key words: α-Galactosylceramide, α-Galactosylceramide, NKT cell activation, NKT cell activation, Glycolipid, Glycolipid, Immunoregulatory agent, Immunoregulatory agent, Structure-activity relationship, Structure-activity relationship, ,

Supporting:

Lei Zhang, Xin-Shan Ye*. Structure modifications based on KRN7000 and their SARs in activating NKT cells[J]. .

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