Abstract:

In the present study, we aimed to assess the comparative efficacy of low-molecular-weight heparin (LMWH) in combination with low-dose aspirin for the management of recurrent miscarriage and scrutinize alterations in coagulation function following such treatment. A retrospective analysis was conducted on clinical data obtained from 97 patients with recurrent miscarriage treated at our institution from January 2019 to June 2020. Patients were categorized into either the study or control groups based on the administration of LMWH. The control group comprised 48 patients treated solely with aspirin, while the study group included 49 patients treated with both LMWH and aspirin. Comparative evaluations between the two groups encompassed pregnancy outcomes, coagulation function, adverse reactions, and blood loss during delivery. Results revealed a higher term birth rate in the study group (83.67%) compared to the control group (50%). Post-treatment, the study group exhibited lower prothrombin time, plasminogen activator inhibitor, and D-dimer levels than the control group. Moreover, the study group experienced fewer adverse reactions and reduced blood loss during delivery in comparison to the control group, demonstrating statistical significance (P < 0.05). The combination of LMWH and low-dose aspirin exhibited noteworthy application in the management of recurrent miscarriage. This therapeutic approach not only fostered the enhancement of coagulation function conducive to pregnancy but also diminished the incidence of adverse reactions observed with aspirin alone.

Key words: Recurrent miscarriage, Low-molecular-weight heparin, Aspirin, Full production, Coagulation function