Advancements in glucagon-like peptide-1 receptor agonist therapy for type 2 diabetes

doi:10.5246/jcps.2024.08.050

Abstract

Abstract:

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel hypoglycemic agents that have garnered widespread acceptance in the treatment of type 2 diabetes, largely attributed to their safety profile, potent hypoglycemic effects, and metabolic advantages. Their primary mechanisms of action encompass promoting insulin release, inhibiting glucagon secretion, bolstering pancreatic islet cell function, curbing appetite, and slowing gastric emptying. This article delves into the clinical evidence underscoring the efficacy of various GLP-1RAs. Notably, these agents have demonstrated marked improvements in glycemic control, significant weight reduction, and substantial cardiovascular and renal protection. Nonetheless, certain adverse effects of GLP-1RAs, such as pancreatitis and intestinal obstruction, have been reported, warranting vigilant monitoring by healthcare professionals. In sum, GLP-1RAs hold significant promise in the management of type 2 diabetes, offering notable cardiovascular and renal advantages.

Key words: Glucagon-like peptide-1 receptor agonist, Type 2 diabetes, Metabolic diseases

Supporting:

Yaping Peng, Ying Fu. Advancements in glucagon-like peptide-1 receptor agonist therapy for type 2 diabetes[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(8): 667-685.

Figures/Tables 2

References 82

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