Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77

doi:10.5246/jcps.2021.01.004

Abstract

Abstract:

Chemical examination of fermentation products of a deep-sea-derived fungus Aspergillus versicolor F77 led to the isolation of two new compounds acetyl-sydonol (1) and 2-hydroxydiorcinol D (2), a new natural product 1-(2,4-dimethoxyphenyl)-1,2-dihydro-3H-pyrazol-3-one (3), together with four known compounds sydonol (4), (S)-sydonic acid (5), aspergillusene A (6) and diorcinol D (7). Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature. Compound 6 showed moderate NF-κB inhibitory activity.

Key words: Deep-sea-derived fungi, Aspergillus versicolor, Secondary metabolites, NF-κB inhibitory activitiy

Supporting:

Ying Kang, Chanjuan Zhang, He Zhang, Dong Liu. Secondary metabolites from a deep-sea-derived Aspergillus versicolor F77[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(1): 42-48.

Figures/Tables 8

Table 1. The 1H and 13C NMR data of compound 1 (DMSO-d6).

Table 2. The 1H and 13C NMR data of compound 2 (DMSO-d6).

Table 3. The 1H and 13C NMR data of compound 3 (DMSO-d6).

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