Chemical constituents from the red alga Symphyocladia latiuscula

doi:10.5246/jcps.2017.10.085

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (10): 754-762.DOI: 10.5246/jcps.2017.10.085

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Chemical constituents from the red alga Symphyocladia latiuscula

Weijie Guo, Guoliang Li, Yuxue Hou, Rongrong Wang, Yang Liu, Xiaohong Liu, Hua Gao, Wei Wang^*

Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China

Received:2017-06-12 Revised:2017-09-26 Online:2017-10-31 Published:2017-09-30
Contact: Tel.: +86-0532-82991172, E-mail: qddxwangwei@qdu.edu.cn
Supported by:
National Natural Sciences Foundation of China (Grant No. 30672599).

Abstract

Abstract:

The extraction and solvent fractionation of red alga Symphyocladia latiuscula, and repeated column chromatography led to isolation of 17 compounds: cholesterol (1), 3β,5β-dihydroxy-B-norcholestan-6β-carboxaldehyde(2),6β-hydroxy-cholest-4-ene-3-one(3), 1-O-myristoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl)glycerol (4), 1-O-palmitoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl)glycerol (5), 1-O-palmitoyl-3-O-[α–D-galactopyranosyl(1→6)β-D-galactopyranosyl] glycerol(6), 1-O-palmitoyl-3-O-β-D-galactopyranosylglycerol (7), methyl hexadecanoate (8), methyl stearate(9), hexadecanoic acid (10), γ-n-butyl cis-aconiate (11), α-n-Butyl cis-aconiate (12), phenethylamine (13),3,5-dibromo-L-tyrosine (14), 3-methylbutylamine (15),methyl pyroglutamate (16),n-butyl pyroglutamate (17).The structures of these compounds were identified by NMR spectroscopy and mass spectrometry, and compared with those reported in the literature. All the compounds were isolated from Symphyocladia genus for the first time.These compounds were investigated for their inhibitory effects on human recombinant aldose reductase in vitro. Of the compounds, 1-O-palmitoyl-3-O-β-D-galactopyranosylglycerol (7) demonstrated moderate enzyme inhibition.

Key words: Symphyocladia latiuscila, Sterols, Glycolipids, Aldose reductase

CLC Number:

R284

Supporting:

Weijie Guo, Guoliang Li, Yuxue Hou, Rongrong Wang, Yang Liu, Xiaohong Liu, Hua Gao, Wei Wang. Chemical constituents from the red alga Symphyocladia latiuscula[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(10): 754-762.

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Chemical constituents from the red alga Symphyocladia latiuscula

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