Lappaconitine solid dispersion monolithic osmotic tablet and lappaconitine push-pull osmotic pump: preparation and comparison of their release performance in vitro

doi:10.5246/jcps.2017.06.045

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (6): 413-422.DOI: 10.5246/jcps.2017.06.045

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Lappaconitine solid dispersion monolithic osmotic tablet and lappaconitine push-pull osmotic pump: preparation and comparison of their release performance in vitro

Xianchuang Wu¹, Jiaojiao Wang², Haijun Hao^2*, Xiaoyong Song^1*, Yongzhou Zhang¹, Yuxin Liu¹, Hongqin Zhang³

1. Department of Pharmacy, Huai He Hospital of Henan University, Kaifeng 475000
2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437
3. Shanghai Advanced Vehicle Technology Pharmaceutical L.T.D. Co, Shanghai 201203

Received:2017-02-15 Revised:2017-04-20 Online:2017-06-29 Published:2017-04-25
Contact: Tel.: +86-021-50272000-1041; +86-0371-23906970, E-mail: haohj2007@126.com; sxyyjk@sina.com
Supported by:
Science and Technology Department of Henan Province Fund Project (Grant No. 144300510019).

Abstract

Abstract:

Lappaconitine is a water-insoluble drug, which was used as model drug in this study. Currently, two osmotically controlleddelivery systems that are widely used for water-insoluble drug are monolithic osmotic tablet (MOT) and push–pull osmotic pump (PPOP). In the present study, lappaconitine solid dispersion monolithic osmotic tablet (lappaconitine-SD-MOT) and lappaconitine-PPOP were developed. The prepared lappaconitine-PPOP was able to delivery drug at the rate of approximate zero-order (r = 0.9931), and the cumulative release was above 95.0%. The lappaconitine-SD-MOT showed a comparatively poor linearity when the data were plotted according to the zero-order equation (r = 0.9798), and the cumulative release was 84.69%. Lappaconitine-PPOP exhibited better controlled drug release (higher regression value) compared with lappaconitine-SD-MOT. The similarity index (f₂) between lappaconitine-PPOP and lappaconitine-SD-MOT was 49.1 (<50). A clear difference of drug release characteristics between the lappaconitine-SD-MOT and lappaconitine-PPOP was revealed. It indicated that the drug release performance of lappaconitine-PPOPcould gain favorable zero-order kinetics and higher cumulative release compared with lappaconitine-SD-MOT. Therefore, these results suggested that PPOP was still a very effective device for the delivery of poorly water-soluble drug with zero-order pattern.

Key words: Lappaconitine, Solid dispersion, Monolithic osmotic tablet, Push-pull osmotic pumps

CLC Number:

R943

Supporting:

Xianchuang Wu, Jiaojiao Wang, Haijun Hao, Xiaoyong Song, Yongzhou Zhang, Yuxin Liu, Hongqin Zhang. Lappaconitine solid dispersion monolithic osmotic tablet and lappaconitine push-pull osmotic pump: preparation and comparison of their release performance in vitro[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(6): 413-422.

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Lappaconitine solid dispersion monolithic osmotic tablet and lappaconitine push-pull osmotic pump: preparation and comparison of their release performance in vitro

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