Protective Effects of Oral Fructose-1, 6-diphosphate on Liver Injury in Animal Models

Abstract

Abstract:

Aim To investigate the effects of FDP on different liver injury models to explore the possibility of FDP used as an oral liver protective agent. Methods Chronic liver injury model in ratswas induced by carbon tetrachloride (CCl4); Acuteliver injury model in micewas induced by aminogalactose (GaIN) or lipopolysaccharide (LPS). Results In CCl4 -induced chronic liver injury model, FDP (1 – 4 g·kg^-1·d^-1, q.d., for 10 weeks) significantly lowered ALT, AST, γ-glutamyl transpeptidase(γ-GT), alkaline phosphatase (ALP), and total bilirubin (T-BIL)in serum compared with vehicle; simultaneously it evidently elevated abnormal total protein (TP), albumin (ALB) and total cholesterol ( T-CHO ) levels in serum; italso dose-dependently reduced hydroxyproline contentsin hepatic tissue. 4 g·kg^-1·d^-1 of FDP apparently decreased incidence of hepatic cirrhosis,and alleviated pathological changes of liver tissue. In GaIN-induced model, 1.0 – 4.0 g·kg^-1·d^-1 of FDP (bid, for 3 d) significantly lowered alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) levels in serum; it also decreased liver coefficient.4.0 g·kg^-1·d^-1 of FDPsignificantly alleviated pathological changes of cell ultra-structures. In LPS-induced model, only high dose of FDP(4.0 g·kg^-1·d^-1, bid, for 12 d) significantly decreased ALT level in serum. Conclusion This study first demonstrated the protective effectof oral FDP on chronic liver injury caused by CCl4 , and confirmed its effect on acute liver injury at the same time, suggesting thatLong-term oral FDPis efficacious against liver injuryinduced by different factorsand can be used as an oral liver protective agent in clinic.

Key words: liver injury, liver injury, oral fructose-1,6-diphosphate, oral fructose-1,6-diphosphate, animal models, animal models

CLC Number:

R965

R975.5

Supporting:

LIUXiao-yan, LI Feng-yun , CHI Zhi-hong, WANG Yin-ye^*. Protective Effects of Oral Fructose-1, 6-diphosphate on Liver Injury in Animal Models[J]. .

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