Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

doi:10.5246/jcps.2015.10.086

Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (10): 673-677.DOI: 10.5246/jcps.2015.10.086

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Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

Farya Zafar¹, Huma Ali¹, Shabana Naz Shah², Safila Naveed^3*, Shehla Siddiqui¹

1. Faculty of Pharmacy, Ziauddin University, Karachi 74700, Pakistan
2. Martin Dow Pharmaceutical Pakistan Limited, Martin, Karachi 75632, Pakistan
3. Jinnah University for Woman Karachi, Karachi 74600, Pakistan

Received:2015-05-25 Revised:2015-06-30 Online:2015-10-21 Published:2015-07-15
Contact: Tel.: 03002621917, E-mail: safila117@yahoo.com

Abstract

Abstract:

In the present study, we aimed todetermine the quality of different brands (Test₁–Test₆) of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, including weight variation, hardness, thickness, friability, disintegration, assay and drug release, were carried out. Results were found to be in acceptable limits. Moreover, release profiles were compared using different dissolution media, such as phosphate buffer pH 6.8, 7.4 and biorelevant media (FaSSGF, FaSSIF, FeSSIF and SCoF). Release profiles at pH 6.8 and 7.4 were evaluated by one-way ANOVA, model-independent and model-dependent methods. Results of ANOVA showed that no significant difference was found among tester and reference brands (Test₁–Test₆). Similarly, all the brands were found to be best fitted with Weibull model.

Key words: Mefenamic acid, One-way ANOVA, Model-independent, Model-dependent method, Biorelevant media

CLC Number:

R944.4

Supporting:

Farya Zafar, Huma Ali, Shabana Naz Shah, Safila Naveed, Shehla Siddiqui. Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(10): 673-677.

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Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi

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