Synthesis of N(OMe)-linked TF antigen analogue

doi:10.5246/jcps.2015.06.046

Abstract

Abstract:

Tumor-associated carbohydrate antigens (TACAs), important molecular markers on tumor cells, are major targets for the development of anti-cancer vaccines. However, due to the immunotolerance and weak immunogenicity, native TACAs cannotinduce powerful immune response. The use of modified TACAs such as N-glycosides could be an alternative strategy to overcomethis problem. Herein, the synthesis of N(OMe)-linked analogue of tumor-associated disaccharide antigen Thomsen-Friedenreich (TF) by the glycosylation reaction is described.

Key words: Tumor-associated carbohydrate antigen, TF, N-glycoside, Glycosylation, Carbohydrate

CLC Number:

R916

Supporting:

Shuang Sun, Yanyan Liu, Yafei Cao, Youhong Niu, Qin Li, Xin-Shan Ye. Synthesis of N(OMe)-linked TF antigen analogue[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(6): 356-363.

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