Statistical optimization and in vivo evaluation of colon specific delivery system of herbal rhubarb extract

doi:10.5246/jcps.2013.06.072

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Statistical optimization and in vivo evaluation of colon specific delivery system of herbal rhubarb extract

Biraju Patel^*, Dhaval Patel, Jayant Chavda, Ravi Manek, Dhaval Mori

1. Department of Pharmaceutics, Smt. R.B.Patel Mahila Pharmacy College, Rajkot, Gujarat, India
2. Department of Pharmaceutics, B.K. Mody Govt. Pharmacy College, Rajkot, Gujarat, India

Received:2013-04-01 Revised:2013-05-07 Online:2013-11-15 Published:2014-01-22
Contact: Biraju Patel*

Abstract

Abstract:

The present research effort was aimed to develop colon targeted drug delivery system (CTDDS) of rhubarb, herbal drug using a mixed film of pectin and ethyl cellulose (EC). Pectin and ethyl cellulose were mixed in various proportions to coat the core tablet to target colon. The methanolic extract of rhubarb was used and the dose of the extract in each formulation was finalized by estimating the emodin content in it by high performace thin layer chromatography (HPTLC). In vitro drug release, erosion study in presence and absence of pectinase enzyme and release constant (K) of zero order was measured for each formulation. The formulation was optimized by using 3²full factorial design. Formulation having 50% pectin as a coating polymer with 12% coat weight was selected as an optimized formulation (OF) on the basis of % similarity with maximum desirability but this formulation was not able to retard the release of drug in stomach and upper intestine fully. So it was further coated with Eudragit S100 (ES) (3% coat weight). The optimized formulation, coated with ES indicated significant laxative activity on loperamide induced constipation in rats. The results revealed that CTDDS of rhubarb using two combined approaches of biodegrable microflora-activated system and pH-sensitive system exhibited a promising colon targeting performance.

Key words: Rhubarb, Pectin, Ethyl cellulose, Eudragit S100, 32 Full factorial design, Y360 min

CLC Number:

R965

Supporting:

Biraju Patel^*, Dhaval Patel, Jayant Chavda, Ravi Manek, Dhaval Mori. Statistical optimization and in vivo evaluation of colon specific delivery system of herbal rhubarb extract [J]. , DOI: 10.5246/jcps.2013.06.072.

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[2]	Pallavi M. Chaudhari, Pravin D. Chaudhari. Formulation and characterization of extruded and spheronized pellets using pectin and crosslinking agents [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(11): 790-798.
[3]	Bao-Jian Wu, Xiu-Li Wei, Yi Lu, Wei Wu^* . Optimization of the biphasic release of indomethacin from HPMC/pectin/calcium chloride matrix tablet by response surface methodology [J]. , 2008, 17(4): 285-290.
[4]	Xu Guojie, Zhang Ruhua, Chu Wei, Hisakazu Sunada. Water Penetration, Matrix Swell and Drug Release Property Studies of Hydroxypropylmethyl Cellulose Matrix Tablets [J]. , 2000, 9(1): 26-30.
[5]	Lu-Wen Shi, Chun-Su Lu, Jun-Hua Zheng, Zhi-Cen Lou. SOD-like Activities of Fifteen Constituents from Rhubarb [J]. , 1992, 1(2): 59-64.

Statistical optimization and in vivo evaluation of colon specific delivery system of herbal rhubarb extract

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