Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants

doi:10.5246/jcps.2013.05.056

Abstract

Abstract:

Many active constituents from herbal plants have well-established pharmacological effects in vitro. But they demonstrate less or no activities in vivo due to various problems of themselves, which severely restricts their clinical applications. After forming phytosomes with phospholipids in aprotic solvent, the active constituents exhibit different physicochemical properties from the free form. In particular, the bioavailability of the active constituent-phytosomes is enhanced greatly due to the improved capacity to cross the biomembrane and reach circulation. Therefore, increasing attention has been attracted to the use of phytosomes in recent years. Based on the published reports, we reviewed the recent progress in the research of phytosomes including preparation, characterization, structure verification and clinical applications.

Key words: Phospholipids, Phytosomes, Active constituents, Bioavailability

CLC Number:

R945.1

Supporting:

Haijun Hao^*, Youzhi Jia, Ru Han. Phytosomes: an effective approach to enhance the oral bioavailability of active constituents extracted from plants [J]. , DOI: 10.5246/jcps.2013.05.056.

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