In vivo antioxidant activity and its protective effects of green tea extract on acute myocardial infarction

doi:10.5246/jcps.2013.04.049

Abstract

Abstract:

The antioxidant activity and its protective effects of Green Tea Extract (GTE) from a Chinese green tea, Hangzhou Longjing, on acute myocardial infarction (AMI) were investigated in rats. Blood, liver and heart were collected to perform DNA damage test, hepatic antioxidant test, gene expression as well as capillary distribution study. A well-known angiotensin II type 1 receptor antagonist, Losartan was used as control. It was found there were significant reductions in certain DNA damage products' levels in GTE and Losartan treated groups compared to saline-treated group. In addition, significant increases in antioxidant enzyme activities and antioxidant gene expressions were observed in GTE and Losartan treated groups. Morphological study also demonstrated the cardioprotective effects of GTE on AMI. In conclusion, GTE has potent and similar cardioprotective effect as Losartan that may due to its ability to scavenge free radicals.

Key words: Myocardial infarction, Green Tea Extract, Antioxidant activity, Cardioprotective effects, In vivo, Losartan

CLC Number:

Supporting:

Rinkiko Suguro, Bo Wei, Ying Wang, Renqiang Li, Sheng Xiong^*. In vivo antioxidant activity and its protective effects of green tea extract
on acute myocardial infarction[J]. , DOI: 10.5246/jcps.2013.04.049.

References

[1] Mustafic, H.; Jabre, P.; Caussin, C.; Murad, M.H.; Escolano, S.; Tafflet, M.; Perier, M.C.; Marijon, E.; Vernerey, D.; Empana, J.P.; Jouven, X. JAMA. 2012, 307, 713-721.
[2] Penna, C.; Perrelli, M.G.; Pagliaro, P. Antioxid. Redox Signal. 2012.
[3] Zhu, Y.Z.; Zhu, Y.C.; Gohlke, P.; Unger, T. ACE Inhibition and Target Organ Protection, Oxford: Euromed Communications Ltd, 1998.
[4] Dodson, J.A.; Arnold, S.V.; Reid, K.J.; Gill, T.M.; Rich, M.W.; Masoudi, F.A.; Spertus, J.A.; Krumholz, H.M.; Alexander, K.P. Am. Heart J. 2012, 163, 790-796.
[5] Zhu, Y.Z.; Huang, S.H.; Tan, B.K.; Sun, J.; Whiteman, M.; Zhu, Y.C. Nat. Prod. Rep. 2004, 21, 478-489.
[6] Sun, J.; Huang, S.H.; Tan, B.K.; Whiteman, M.; Zhu, Y.C.; Wu, Y.J.; Ng, Y.; Duan, W.; Zhu, Y.Z. Life Sci. 2005, 76, 2849-2860.
[7] Sun, J.; Huang, S.H.; Zhu, Y.C.; Whiteman, M.; Wang, M.J.; Tan, B.K.; Zhu, Y.Z. Life Sci. 2005, 76, 3043-3056.
[8] Dhalla, N.S.; Elmoselhi, A.B.; Hata, T.; Makino, N. Cardiovasc. Res. 2000, 47, 446-456.
[9] Hori, M.; Nishida, K. Cardiovasc. Res. 2009, 81, 457-464.
[10] Hodgson, J.M.; Croft, K.D. Mol. Aspects Med. 2010, 31, 495-502.
[11] Sun, J.Z.; Cao, L.H.; Liu, H. Hypertens. Res. 2011, 34, 15-22.
[12] Zhu, Y.Z.; Zhu, Y.C. Science Online. 2002.
[13] Blumberg, J. J. Nutr. 2003, 133, 3244S-3246S.
[14] Cheng, T.O. Int. J. Cardiol. 2006, 108, 301-308.
[15] Antonello, M.; Montemurro, D.; Bolognesi, M.; Di Pascoli, M.; Piva, A.; Grego, F.; Sticchi, D.; Giuliani, L.; Garbisa, S.; Rossi, G.P. Am. J. Hypertens. 2007, 20, 1321-1328.
[16] Abolfathi, A.A.; Mohajeri, D.; Rezaie, A.; Nazeri, M. Evid. Based Complement. Alternat. Med. 2012, 2012, 740671.
[17] Bogdanski, P.; Suliburska, J.; Szulinska, M.; Stepien, M.; Pupek-Musialik, D.; Jablecka, A. Nutr. Res. 2012, 32, 421-427.
[18] Bornhoeft, J.; Castaneda, D.; Nemoseck, T.; Wang, P.; Henning, S.M.; Hong, M.Y. J. Med. Food. 2012, 15, 726-732.
[19] Suzuki, K.; Ohno, S.; Suzuki, Y.; Ohno, Y.; Okuyama, R.; Aruga, A.; Yamamoto, M.; Ishihara, K.O.; Nozaki, T.; Miura, S.; Yoshioka, H.; Mori, Y. Anticancer Res. 2012, 32, 2369-2375.
[20] Ji, X.; Tan, B.K.; Zhu, Y.C.; Linz, W.; Zhu, Y.Z. Life Sci. 2003, 73, 1413-1426.
[21] Whiteman, M.; Huang, S.H.; Jenner, A.; Halliwell, B. Biochem. Biophys. Res. Commun. 2002, 296, 883-889.
[22] Kruger, N.J. Methods Mol. Biol. 1994, 32, 9-15.
[23] Awasthi, Y.C.; Beutler, E.; Srivastava, S.K. J. Biol. Chem. 1975, 250, 5144-5149.
[24] Chomczynski, P.; Sacchi, N. Anal. Biochem. 1987, 162, 156-159.
[25] van Kimmenade, R.R.; Januzzi, J.L.Jr. Clin. Chem. 2012, 58, 127-138.

In vivo antioxidant activity and its protective effects of green tea extract
on acute myocardial infarction

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Kunpeng Yao, Daoping Zhang, Qili Liu, Huzhi Cai, Qingyang Chen, Xinyu Chen. Integrating bioinformatics to identify and analyze feature genes of acute myocardial infarction and potential Chinese medicine prediction [J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(12): 912-927.
[2]	Suryati, Elida Mardiah, Mai Efdi, Kartika MZ, Yuni Mala Sari. Bioactivity of compounds isolated from the leaves of the Lantana camara Linn plant [J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(5): 360-368.
[3]	Yanli Hao, Ting Zhong, Ruo Du, Hua Zhang, Bilin Liu, Xuan Zhang. The cellular uptake and anti-tumor activity of conjugated linoleic acid-paclitaxel-loaded iRGD-modified lysolipid-containing thermosensitive liposomes [J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(2): 121-133.
[4]	Yuqing Meng, Lichao Wang, Yan Li, Jinyang Song, Zhiyong Du, Chun Li, Yong Jiang, Pengfei Tu, Xiaoyu Guo. Cardioprotective effects of combination of notoginseng total saponins and safflower total flavonoids against myocardial infarction in rats [J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(2): 116-122.
[5]	Dechun Liu, Dan Yang, Bing He, Wenbing Dai, Hua Zhang, Xueqing Wang, Lan Yuan, Qiang Zhang, Xing Tang. A practical method to trace intracellular and transcellular transport pathways of gold nanoparticles via oral administration [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(10): 737-746.
[6]	Jianhui Chen, Xiaowen Ma, Zhao Zhang, Yingqi Zhang, Yuan Yuan, Meng Li. An Ac-SDKP analogue resistant to angiotensin converting enzyme exhibits anti-fibrosis effects and improves heart function in mice after myocardial infarction [J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(12): 789-800.
[7]	Lu Yang, Lulu Sun, Tao Guo, Dongya Xia, Xipei Wang, Xingang Li, Wei Lu. Population pharmacokinetic of losartan and its active metabolite E-3174 in five different ethnic populations of China [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(8): 548-557.
[8]	Tianxing Shi, Yuguang Li, Yong Jiang^*, Pengfei Tu. Isolation of flavonoids from the aerial parts of Polygala tenuifolia Willd. and their antioxidant activities [J]. , 2013, 22(1): 36-39.
[9]	Hua Zheng, Wenjie Hou, Jiancheng Wang^*, Qiang Zhang. PEG-PCL nanomicelles for cancer theranosis: targeted imaging and drug delivery [J]. , 2012, 21(6): 591-597.
[10]	Han Zhong, Hong Xin, Yi-Zhun Zhu^*. Cardioprotective effects of Chinese herbal medicine Braintone on myocardial infarction in rats [J]. , 2010, 19(3): 186-194.
[11]	Chang-Qing Chen^#, Hong Xin^#, Yi-Chun Zhu, Yi-Zhun Zhu^* . Cardioprotective effects of hydrogen sulfide and nitric oxide and their interactions during the process of myocardial ischemia in rats [J]. , 2009, 18(1): 64-72.
[12]	Xue Zhang, Jie-Kun Xu, Nai-Li Wang, Hiroshi Kurihara, Xin-Sheng Yao^* . Antioxidant phenanthrenes and lignans from Dendrobium nobile [J]. , 2008, 17(4): 314-318.
[13]	Zhi-Hong Zhang, Chang-Guang Wang, Guang-Mei Sun, Ning Li, Bo Peng, Wei-San Pan^* . Pharmacokinetics of two modified release system of dipyridamole in beagle dogs [J]. , 2008, 17(4): 297-302.
[14]	YANG Ping, LI Lin, SUN Jin, HE Zhong-gui^*. Bioequivalent Evaluation of Two Brands of Losartan/Hydrochlorothiazide Compound Tablets in Healthy Chinese Male Volunteers [J]. , 2006, 15(3): 162-167.
[15]	Guo Zhibin, Li Qing, Cao Hongyu, Xu Zhi . Antiarrhythmic Efficacy of Neferine Assessed by Programmed Electrical Stimulation in a Canine Model of Electropharmacology [J]. , 2002, 11(2): 35-42.