Abstract:

Aim To investigate the alkylation of 2-thiopyrimidine. Methods Treating the starting material 2-thiopyrimidine with chloromethyl ethers via a procedure of K2CO3 in DMF or with alkyl halide in CH3ONa-CH3OH at room temperature, to obtain the corresponding regioselective 2-S-allkyl pyrimidines. The products were determined by ¹H NMR, 2D NMR, IR and MS spectra. Results 2-S-alkyl-pyrimidines were regioselectively synthesized. Conclusion In different conditions with different alkyl halides, 2- thiouracil could be converted into the corresponding 2-S-alkylpyrimidines regioselectively.

Key words: Alkylation, Alkylation, 2-Thio-6-methyl-uracil, 2-Thio-6-methyl-uracil, 2-Alkylthiopyrimidine, 2-Alkylthiopyrimidine, 6-Methyl-3,4-dihydro-2H-pyrido [2,1-b] [1,3] thiazin-8-one, 6-Methyl-3,4-dihydro-2H-pyrido [2,1-b] [1,3] thiazin-8-one