Abstract: Aim Liposomal fluconazole gel was prepared and its properties were studied. Methods The fluconazole liposomes were prepared by film dispersion method. Their shapes and sizes were observed by transmission electronic microscope and particle size analyzer, respectively. The skin permeation of liposomal gel was studied on rat skin by permeation cell. Results The entrapment efficiency of fluconazole liposomes was 47.68%. The fluconazole liposomes were oval or round in shape, and their average diameter was 250 ± 8 nm. The accumulative skin permeation of liposomal fluconazole gel (25.27%) was lower than that of non-liposomal fluconazole gel (36.72%), but fluconazole retained in rat skin of liposomal gel (162 ± 15 μg·cm^–2) was higher than that of nonliposomal gel (48 ± 6 μg·cm^–2). Conclusion Liposomal fluconazole gel can significantly increase the deposited amounts of fluconazole in rat skin and it may be beneficial for topical use.

Key words: Fluconazole, Fluconazole, Liposomal gel, Liposomal gel, Transdermal delivery, Transdermal delivery, in vitro, in vitro, ,