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Preparation of a novel activated carbon microsphere and its in vitro adsorption characteristics for biological molecules

Yi-Ni Xie, Feng Gao*, Hui-Hui Yuan, Xiao-Yi Liang, Li-Cheng Ling   

  1. 1. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China
    2. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
    3. School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
  • Received:2010-12-14 Revised:2011-03-10 Online:2011-05-06 Published:2011-05-06
  • Contact: Feng Gao*

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Abstract:

We prepared a novel pitch-based activated carbon microsphere (ACM) and studied its in vitro adsorption characteristics for biological molecules. The original spherical asphalt particles were prepared through bitumen emulsification. After oxidation and burning, ACMs with a range of parameters were prepared. In vitro adsorption experiments of ACMs for biological molecules were carried out. The prepared ACMs possessed a BET specific surface of 1566 m2/g with a voidage of 0.653 cm3/g and a volume of micropores of 0.478 cm3/g. They showed high adsorption for glucose and creatintine. Compared with the medically used carbon powder, the prepared ACMs exhibited significantly lower adsorption for digestion enzymes. In conclusion, the prepared ACMs, as an oral adsorbent candidate, possessed higher BET specific surface area and larger volume of micropores; they also exhibited favorable selective adsorption features for biological molecules.

Key words: Activated carbon microsphere, Porous structure, Adsorption characteristics, Biological molecules, Digestion enzymes

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